A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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PREMARIN cream (conjugated estrogens) is a medication prescribed to treat atrophic vaginitis (thinning, drying, and inflammation of the vaginal walls) and kraurosis vulvae (shrinkage of the skin of the vagina and vulva). PREMARIN cream may also be prescribed to treat dyspareunia (pain or difficulty during intercourse).
After menopause, the levels of circulating estrogen decreases. Additionally, different types of estrogens are present than pre-menopause. PREMARIN works by increasing levels of the levels of certain estrogens and decreasing circulating luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Increasing levels of estrogen help to maintain secondary sexual characteristics.
When treating atrophic vaginitis or kraurosis vulvae, the typical dosage of PREMARIN is 0.5 g once daily intravaginally for 7 days on and 21 days off. Use the included applicator to measure the appropriate dose.
When treating dyspareunia, the typical dose is 0.5 g twice weekly.
The active ingredients in PREMARIN cream are conjugated estrogens — sodium estrone sulfate, sodium equilin sulfate, 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin.
The inactive ingredients include benzyl alcohol, cetyl alcohol, cetyl esters wax, glycerin, glyceryl monostearate, mineral oil, methyl stearate, and white wax.
Estrogens have been shown to increase the risk of stroke and deep vein thrombosis (DVT) in postmenopausal women. The increased risk has been shown with daily oral estrogen supplements, and the risk is probably lower for topical formulations.
Daily oral estrogens have also been shown to increase the risk of myocardial infarction (heart attack), invasive breast cancer, pulmonary emboli, and uterine cancer. This risk is probably not as great for topical formulations.
Due to the increased risk of the above-listed health conditions, PREMARIN cream should be used for the shortest amount of time at the lowest possible dose.
Speak to your doctor for a full list of cautions before using PREMARIN cream.
The most common side effects of PREMARIN cream include:
Speak with your doctor for a full list of possible side effects. Systemic side effects may also occur.